Open AccessA STUDY OF THE PHYSICOCHEMICAL CHARACTER OF THE INTERACTION OF THE LIPOSOME CONTAINING OLEIC ACID OF THE LIQUID-CRYSTAL STATE AND BIOMEMBRANE
Author(s) -
Jing Zhang,
RunCang Sun
Publication year - 1994
Publication title -
wuli xuebao
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.199
H-Index - 47
ISSN - 1000-3290
DOI - 10.7498/aps.43.1495
Subject(s) - oleic acid , liposome , materials science , lamellar structure , polyvinylpyrrolidone , small angle x ray scattering , crystallization , liquid crystal , lamellar phase , crystallography , chemistry , organic chemistry , scattering , polymer chemistry , optics , nanotechnology , composite material , biochemistry , physics , optoelectronics
The structure of the liquid crystal state of the new antiturner agent, polyphase liposome containing oleic acid, has been studied by small angle puiypnase scattering (SAXS) and 31P nuclear magnetism resomance (31P-NMR). Experimental results show that the presence of cholesterol, oleic acid, nonionic surfactant will highly affect the structure of the liquid crystal state of the PE liposome containing oleic acid. The liquid crystal state of liposome with oleic acid made from phosphoric buffer solution containing polyvinylpyrrolidone consists of both lamellar-hexagonal phase and lamellar-cubic phase. Electron-spin-resonance (ESR) experiment shows that the W/S value in the Ehrlich ascites tumor cell increases as the amount of liposome increases.