Open AccessHIV Drug Therapy in the Americas 16–18 April 2015, Mexico City, Mexico
Author(s) -
Mike Lederman,
Sergio BautistaArredondo,
Stefano Bertozzi,
Sandra SosaRubi,
Roy Gulick,
Carlos Rio,
Chris Beyrer,
Esmeralda Román,
Hamid VegaRamirez,
Jeremy Cruz,
Jesús CasillasRodríguez,
Andrea GonzálezRodríguez,
Pablo BelaunzaránZamudio,
Juan SierraMadero,
Gabriela Bugarin,
César Rivera,
Isabel Cassetti,
Patricia Vasquez,
José Valdez Madruga,
Jean van Wyk,
Marisol MartinezTristani,
Omar Sued,
Timothy R Sterling,
Brenda Crabtree Ramírez,
Yanink CaroVega,
Bryan Shepherd,
Beatriz Grinsztejn,
Marcelo Wolff,
Claudia Cortés,
Denis Padgett,
Gabriela Carriquiry,
Valeria Fink,
Karu Jayathilake,
Anna Person,
Catherine McGowan,
Daniel Kuritzkes,
Jean William Pape,
Jose CastilloMancilla,
Patricia Volkow,
Rafael Campo,
Anton Pozniak,
Mónica Alonso González,
Jorge Santana,
Juergen Rockstroh,
Massimo Puoti,
Maribel RodriguezTorres,
Douglas Dieterich,
Anuj Gaggar,
Liyun Ni,
Benedetta Massetto,
Evguenia Svarovskaia,
Diana Brainard,
Mani Subramanian,
John McHutchison,
Susanggie,
Chloe Orkin,
JeanMichel Molina,
Mark Sulkowski,
Santiago AvilaRios,
Claudia GarcíaMorales,
Daniela TapiaTrejo,
Carlos MejíaVillatoro,
Juan Pascale,
Guillermo PorrasCortes,
Ivette Lorenzana,
Elsa Palou,
Marvin Manzanero,
Gustavo ReyesTerán,
Steven Díaz,
Israel MacíasGonzález,
Ubaldo RamosAlamillo,
Paula Luz,
Carina César,
Fernando MejíaCordero,
Erica Stankievich,
Irene Foradori,
Adriana Malanca,
Silvina Ivalo,
Marcelo Losso,
Robert Paulino,
Natalia Gomez,
Paola Lockhart,
Ellen Koenig,
Adrian Puello,
Hugo Vargas González,
Nathalie Gras Allain,
Omar Galarraga,
Don Operario,
Biani Saavedra,
Kenneth Mayer,
Carlos J CondeGonzalez,
Andrea Gonzalez,
Juan Luis Mosqueda,
Alejandro Macias Hernandez,
Monica Lopez Segura,
Harumi Hirata,
Victor Rodriguez,
Daniela Ferreyra,
Carolina Rocabert,
Aldemir OliveiraFilho,
Pricila Pereira,
Laine Pinto,
Leila Sawada,
Jairo Castro,
Roseane LimaVerde,
José Alexandre Lemos,
Antonio Vallinoto,
Evaldo Oliveira,
Jaime AndradeVillanueva,
Luz GonzálezHernández,
Mara LlamasCovarrubias,
David PonceHerrera,
Raul SoriaRodríguez,
Sergio ZuñigaQuiñonez,
Pedro MartínezAyala,
Teresita Jesús Cabrera López,
Carlos Cruz Palacios,
Elena Langarica Naves,
Chia Wang,
Roger Trinh,
Peter Ruane,
David Wyles,
Joseph Eron,
Laveeza Bhatti,
Yiran Hu,
Barbara McGovern,
Nancy Shulman,
Robert Antonio Duen̈as Dominguez,
Veronica Ruiz,
Oscar Malpartida,
Giancarlo Perez,
Romulo Rodriguez,
Julio Maquera,
Ricardo Illescas,
Lourdes Rodríguez,
Jose Hidalgo,
Ericka Magdalena León Guerrero,
José Álvarez,
Santiago Ignacio Godinez Hernández,
Emilio Francisco Jimenez Guevara,
Andres Gonzalez,
Daniel Escobar,
Jenny Andrea Carmona,
Juan Carlos Gonzalez,
Claudia Frola,
Florencia Straminsky,
Liliana Guelfand,
Héctor Pérez,
Pedro Cahn,
Camille Bernaud,
Audrey Rodallec,
Marine Morrier,
Clotilde Allavena,
Philippe Perre,
Solene Pineau,
Thomas Jovelin,
Nolwenn Hall,
Samuel Pineau,
Elisabeth AndreGarnier,
Francois Raffi,
Emmanuel MercadoNuñez,
José MartínezOlmedo,
Marisol Valenzuela Lara,
Carlos Magis Rodríguez,
Celina Gonçalves,
Miguel Abreu,
Ana Rita Silva,
Josefina Mendez,
Rui Sarmento e Castro,
Gabriela Hernandez,
Gisela Munoz,
Ismael Avila,
Luis SotoRamírez,
Leonardo Chanqueo,
Howard Martin,
Kim Brugger,
Aws Sadik,
Hongyi Zhang,
Jane Greatorex,
Jag Batra,
Hilda Kizito,
Aditya Gaur,
Wasana Prasitsuebsai,
Natella Rakhmanina,
Eileen Lawson,
Yongwu Shao,
Sean Bennett,
Andrew Cheng,
Anita Silva,
Erin Quirk,
Cristina Jesus HerreraCastillo,
Angelica Rodríguez,
Othon RojasMontes,
Rosalia Lira,
José Guillermo VazquezRosales,
Gloria HuertaGarcía,
Leoncio PeregrinoBejarano,
Eric FloresRuiz,
Fortino SolorzanoSantos,
José Antonio MataMarín,
Jose Arribas,
Samir Gupta,
Frank Post,
Anchalee Avihingsa,
Gordon Crofoot,
Kenneth Lichtenstein,
Moti Ramgopal,
Ploenchan Chetchotisakd,
Marshall Fordyce,
Edwin DeJesus,
Paul Sax,
Michael Yin,
Shinichi Oka,
Benoit Trottier,
Huyen Cao,
Julie Ryu,
David Wohl,
Melanie Thompson,
Daniel Podzamczer,
Christian Callebaut,
Hal Martin,
Scott McCallister,
Carlos Beltran,
Tamara Newman,
David Dorey,
Dannae Brown,
Isidoro Prudente,
Sandy Griffith,
Michael Aboud,
Carlos Fernando de Oliveira,
Ana Celi,
Paola Castillo,
Monica Thormann,
Olga Lopez,
Carolina Chahin,
Carlos Gallo,
Carlos Perez,
Alejandro Afani,
Juan Calva,
Carolina LaraSánchez,
Pedro AguilarSalinas,
Mauricio OstroskyFrid
Publication year - 2015
Publication title -
journal of the international aids society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.724
H-Index - 62
ISSN - 1758-2652
DOI - 10.7448/ias.18.3.20177
Subject(s) - medicine , human immunodeficiency virus (hiv) , antiretroviral therapy , viral load , mexico city , inflammation , immune system , immunology , viral replication , gerontology , demography , virus , humanities , philosophy , sociology
Antiretroviral therapies have proved life‐saving in HIV infection, dramatically reducing morbidity and mortality. With longer survival, morbidities and mortalities in HIV infection are increasingly similar to the morbidities and mortalities associated with ageing. In treated HIV infection, the risk of these morbidities and mortalities is linked to immune activation, inflammation and coagulation indices. And in persons with treated HIV infection, failure to restore circulating CD4 T cell numbers is associated with a greater risk of morbidities and mortalities as well as to heightened levels of inflammation and coagulation. The drivers of immune activation, inflammation and coagulation in treated HIV infection are incompletely defined and could be related to sustained low levels of viral replication in tissues, to translocation of microbial products across a damaged gut mucosa, to replication of co‐pathogens such as cytomegalovirus, to increased levels of inflammatory lipids, or to homeostatic responses to lymphocytopenia that may drive expansion of CD8 T cell numbers. We present here models that link inflammation and coagulation to morbid outcomes as well as to the pathogenesis of CD4 T cell restoration failure and CD8 T cell expansion.
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