Open AccessHIV Drug Therapy in the Americas 16–18 April 2015, Mexico City, Mexico
Author(s) -
Mike Lederman,
Sergio BautistaArredondo,
Stefano Bertozzi,
Sandra SosaRubi,
Roy Gulick,
Carlos Rio,
Chris Beyrer,
Esmeralda Román,
Hamid VegaRamirez,
Jeremy Cruz,
Jesús CasillasRodríguez,
Andrea GonzálezRodríguez,
Pablo BelaunzaránZamudio,
Juan SierraMadero,
Gabriela Bugarin,
César Rivera,
Isabel Cassetti,
Patricia Vasquez,
José Valdez Madruga,
Jean van Wyk,
Marisol MartinezTristani,
Omar Sued,
Timothy R Sterling,
Brenda Crabtree Ramírez,
Yanink CaroVega,
Bryan Shepherd,
Beatriz Grinsztejn,
Marcelo Wolff,
Claudia Cortés,
Denis Padgett,
Gabriela Carriquiry,
Valeria Fink,
Pablo BelaunzaránZamudio,
Karu Jayathilake,
Anna Person,
Catherine McGowan,
Juan SierraMadero,
Daniel Kuritzkes,
Jean William Pape,
Juan SierraMadero,
Jose CastilloMancilla,
Patricia Volkow,
Rafael Campo,
Anton Pozniak,
Mónica Alonso González,
Jorge Santana,
Juergen Rockstroh,
Massimo Puoti,
Maribel RodriguezTorres,
Douglas Dieterich,
Anuj Gaggar,
Liyun Ni,
Benedetta Massetto,
Evguenia Svarovskaia,
Diana Brainard,
Mani Subramanian,
John McHutchison,
Susanggie,
Chloe Orkin,
JeanMichel Molina,
Mark Sulkowski,
Santiago AvilaRios,
Claudia GarcíaMorales,
Daniela TapiaTrejo,
Carlos MejíaVillatoro,
Juan Pascale,
Guillermo PorrasCortes,
Ivette Lorenzana,
Elsa Palou,
Marvin Manzanero,
Gustavo ReyesTerán,
Pablo BelaunzaránZamudio,
Andrea GonzálezRodríguez,
Steven Díaz,
Jesús CasillasRodríguez,
Israel MacíasGonzález,
Ubaldo RamosAlamillo,
Pablo BelaunzaránZamudio,
Yanink CaroVega,
Brenda Crabtree Ramírez,
Paula Luz,
Beatriz Grinsztejn,
Carina César,
Claudia Cortés,
Jean William Pape,
Fernando MejíaCordero,
Denis Padgett,
Juan SierraMadero,
Catherine McGowan,
Bryan Shepherd,
Erica Stankievich,
Irene Foradori,
Adriana Malanca,
Silvina Ivalo,
Marcelo Losso,
Robert Paulino,
Natalia Gomez,
Paola Lockhart,
Ellen Koenig,
Adrian Puello,
Paola Lockhart,
Natalia Gomez,
Hugo Vargas González,
Nathalie Gras Allain,
Sandra SosaRubi,
Omar Galarraga,
Don Operario,
Biani Saavedra,
Kenneth Mayer,
Nathalie Gras Allain,
Carlos J CondeGonzalez,
Andrea Gonzalez,
Juan Luis Mosqueda,
Alejandro Macias Hernandez,
Monica Lopez Segura,
Harumi Hirata,
Hamid VegaRamirez,
Jeremy Cruz,
Victor Rodriguez,
Daniela Ferreyra,
Carolina Rocabert,
Aldemir OliveiraFilho,
Pricila Pereira,
Laine Pinto,
Leila Sawada,
Jairo Castro,
Roseane LimaVerde,
José Alexandre Lemos,
Antonio Vallinoto,
Evaldo Oliveira,
Jaime AndradeVillanueva,
Luz GonzálezHernández,
Mara LlamasCovarrubias,
David PonceHerrera,
Raul SoriaRodríguez,
Sergio ZuñigaQuiñonez,
Pedro MartínezAyala,
Teresita Jesús Cabrera López,
Ubaldo RamosAlamillo,
Carlos Cruz Palacios,
Andrea GonzálezRodríguez,
Elena Langarica Naves,
Steven Díaz,
Chia Wang,
Roger Trinh,
Peter Ruane,
David Wyles,
Joseph Eron,
Laveeza Bhatti,
Yiran Hu,
Barbara McGovern,
Nancy Shulman,
Mark Sulkowski,
Robert Antonio Duen̈as Dominguez,
Ubaldo RamosAlamillo,
Veronica Ruiz,
Oscar Malpartida,
Giancarlo Perez,
Romulo Rodriguez,
Julio Maquera,
Ricardo Illescas,
Lourdes Rodríguez,
Jose Hidalgo,
Juan Luis Mosqueda,
Ericka Magdalena León Guerrero,
José Álvarez,
Santiago Ignacio Godinez Hernández,
Emilio Francisco Jimenez Guevara,
Andres Gonzalez,
Daniel Escobar,
Jenny Andrea Carmona,
Juan Carlos Gonzalez,
Claudia Frola,
Omar Sued,
Florencia Straminsky,
Liliana Guelfand,
Héctor Pérez,
Pedro Cahn,
Camille Bernaud,
Audrey Rodallec,
Marine Morrier,
Clotilde Allavena,
Philippe Perre,
Solene Pineau,
Thomas Jovelin,
Nolwenn Hall,
Samuel Pineau,
Elisabeth AndreGarnier,
Francois Raffi,
Luz GonzálezHernández,
Mara LlamasCovarrubias,
Emmanuel MercadoNuñez,
José MartínezOlmedo,
Jaime AndradeVillanueva,
Marisol Valenzuela Lara,
Carlos Magis Rodríguez,
Celina Gonçalves,
Miguel Abreu,
Ana Rita Silva,
Josefina Mendez,
Rui Sarmento e Castro,
Hamid VegaRamirez,
Victor Rodriguez,
Jeremy Cruz,
Harumi Hirata,
Daniela Ferreyra,
Carolina Rocabert,
Gabriela Hernandez,
Gisela Munoz,
Ismael Avila,
Luis SotoRamírez,
Leonardo Chanqueo,
Howard Martin,
Kim Brugger,
Aws Sadik,
Hongyi Zhang,
Jane Greatorex,
Jag Batra,
Hilda Kizito,
Aditya Gaur,
Wasana Prasitsuebsai,
Natella Rakhmanina,
Eileen Lawson,
Yongwu Shao,
Sean Bennett,
Andrew Cheng,
Anita Silva,
Erin Quirk,
Cristina Jesus HerreraCastillo,
Angelica Rodríguez,
Othon RojasMontes,
Rosalia Lira,
José Guillermo VazquezRosales,
Gloria HuertaGarcía,
José Guillermo VazquezRosales,
Leoncio PeregrinoBejarano,
Eric FloresRuiz,
Fortino SolorzanoSantos,
José Antonio MataMarín,
Anton Pozniak,
Jose Arribas,
Samir Gupta,
Frank Post,
Anchalee Avihingsa,
Gordon Crofoot,
Kenneth Lichtenstein,
Moti Ramgopal,
Ploenchan Chetchotisakd,
Marshall Fordyce,
Edwin DeJesus,
Paul Sax,
Michael Yin,
Frank Post,
Shinichi Oka,
Ellen Koenig,
Benoit Trottier,
Huyen Cao,
Julie Ryu,
David Wohl,
Anton Pozniak,
Melanie Thompson,
Daniel Podzamczer,
JeanMichel Molina,
Gordon Crofoot,
Christian Callebaut,
Hal Martin,
Scott McCallister,
Pedro Cahn,
Jaime AndradeVillanueva,
Carlos Beltran,
Tamara Newman,
David Dorey,
Dannae Brown,
Isidoro Prudente,
Sandy Griffith,
Michael Aboud,
Carlos Fernando de Oliveira,
Carlos Beltran,
Omar Sued,
Ana Celi,
Paola Castillo,
Monica Thormann,
Olga Lopez,
Carolina Chahin,
Carlos Gallo,
Carlos Perez,
Alejandro Afani,
Juan Calva,
Carolina LaraSánchez,
Pedro AguilarSalinas,
Mauricio OstroskyFrid
Publication year - 2015
Publication title -
journal of the international aids society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.724
H-Index - 62
ISSN - 1758-2652
DOI - 10.7448/ias.18.3.20177
Subject(s) - medicine , human immunodeficiency virus (hiv) , antiretroviral therapy , viral load , mexico city , inflammation , immune system , immunology , viral replication , gerontology , demography , virus , humanities , philosophy , sociology
Antiretroviral therapies have proved life‐saving in HIV infection, dramatically reducing morbidity and mortality. With longer survival, morbidities and mortalities in HIV infection are increasingly similar to the morbidities and mortalities associated with ageing. In treated HIV infection, the risk of these morbidities and mortalities is linked to immune activation, inflammation and coagulation indices. And in persons with treated HIV infection, failure to restore circulating CD4 T cell numbers is associated with a greater risk of morbidities and mortalities as well as to heightened levels of inflammation and coagulation. The drivers of immune activation, inflammation and coagulation in treated HIV infection are incompletely defined and could be related to sustained low levels of viral replication in tissues, to translocation of microbial products across a damaged gut mucosa, to replication of co‐pathogens such as cytomegalovirus, to increased levels of inflammatory lipids, or to homeostatic responses to lymphocytopenia that may drive expansion of CD8 T cell numbers. We present here models that link inflammation and coagulation to morbid outcomes as well as to the pathogenesis of CD4 T cell restoration failure and CD8 T cell expansion.