Open AccessPrevalence of vitamin D deficiency in human immunodeficiency virus‐infected patients
Author(s) -
Fridman V,
Bello N,
Godoy E,
Stecher D,
Lasala M
Publication year - 2012
Publication title -
journal of the international aids society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.724
H-Index - 62
ISSN - 1758-2652
DOI - 10.7448/ias.15.6.18324
Subject(s) - medicine , vitamin d deficiency , osteomalacia , vitamin d and neurology , osteopenia , osteoporosis , population , viral load , efavirenz , diabetes mellitus , coinfection , pediatrics , gastroenterology , immunology , endocrinology , human immunodeficiency virus (hiv) , bone mineral , antiretroviral therapy , environmental health
Purpose of the study Vitamin D deficiency in the adults could produce osteomalacia, secondary hyperparathyroidism with bone loss and increased risk of fractures. An increased prevalence of osteopenia, osteoporosis, decreased bone density, vitamin D deficiency and increased risk of fracture was found in HIV‐positive patients. A study performed in Buenos Aires, Argentina that included non‐HIV‐infected adult patients showed 15% prevalence of vitamin D deficiency in winter and 0% prevalence in summer. There is no local data published of vitamin D deficiency in HIV‐positive populations. The aim of the study is to determinate the prevalence of vitamin deficiency in our HIV‐positive population receiving HAART. Methods An observational, retrospective study was performed. We reviewed the clinical charts of the HIV‐positive adult patients attending the infectious disease clinic. We collected data of vitamin D, parathormone and beta cross laps value; we recorded if the test was performed in winter or summer. We considered vitamin D deficiency if<10 ng/ml. We recorded age, sex, comorbidities (diabetes mellitus, renal failure, hepatic failure, HBV and/or HCV coinfection, menopause, malignancy and metabolic syndrome), months since HIV diagnosis, CD4 count, viral load and HAART. Summary of results 60 patients were included, 49 (65%) of whom were male. Mean age was 49.15 years. Mean time from diagnosis was 112 months. Mean CD4 count was 548 cells/mm 3 and 6.6% presented CD4 <200; 83.3% had viral load <50 copies/mm 3 . All patients were on HAART; 50% received efavirenz, 65% received tenofovir and 11.6% recived atazanavir. Mean vitamin D value was 23.58 ng/ml (5–66.5 ng/ml). In winter, 15.3% of the patients had <10 ng/ml of vitamin D and mean value was 24.16 ng/ml (10–40 ng/ml). Although the mean value in summer was 25.8 ng/ml (11.6–66 ng/ml) 10% of the patients had vitamin D deficiency. PTH value was abnormal in 31.6% of patients and beta cross laps was abnormal in 10% of patients. Conclusions Although the small number of patient included, we observed a high prevalence of vitamin D deficiency even in summer. A systematic assessment of vitamin D must be included in HIV positive patient care.