Open AccessHIV‐exposed infants on follow up at a PMTCT clinic: risk of HIV transmission and its predictors in north‐west Ethiopia
Author(s) -
Negesse K,
Zeleke M
Publication year - 2012
Publication title -
journal of the international aids society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.724
H-Index - 62
ISSN - 1758-2652
DOI - 10.7448/ias.15.6.18234
Subject(s) - medicine , transmission (telecommunications) , pediatrics , nevirapine , regimen , referral , multivariate analysis , retrospective cohort study , childbirth , human immunodeficiency virus (hiv) , viral load , pregnancy , antiretroviral therapy , family medicine , biology , electrical engineering , genetics , engineering
Background The HIV pandemic created an enormous challenge to the survival of mankind worldwide. Vertical HIV transmission from mother to child accounts for more than 90% of pediatric AIDS. Prevention of mother‐to‐child transmission (PMTCT) programs are provided for dual benefits, i.e. prevention of HIV transmission from mother to child and enrolment of infected pregnant women and their families into antiretroviral treatment. The availability and use of short‐course antiretroviral (ARV) prophylaxis, a safe and well‐tolerated regimen, can contribute significantly to PMTCT during childbirth. This study assessed risk and predictors of HIV transmission among HIV‐exposed infants on follow up at a PMTCT clinic of a referral hospital. Methods Institution‐based retrospective follow‐up study was carried out on all records of HIV‐exposed infants enrolled between September 2005 and July 2011 at Gondar University Hospital PMTCT clinic. Secondary data were collected using a structured data extraction format prepared in English by a trained nurse working at the PMTCT clinic. Data were then entered in to EPI INFO Version 3.5.1 statistical software and analyzed by SPSS version 16.0. Both bivariate and multivariate analyses were carried out to identify variables that had association with vertical HIV transmission. Results A total of 509 records were included in the analysis. The median age of infants at enrolment to follow up was 6 weeks (IQR=2 weeks). A total of 51 (10%) infants were infected with HIV. Late enrolment to the exposed infant follow‐up clinic (AOR=2.89, 95% CI: 1.35, 6.21), rural residence (AOR=5.05, 95% CI: 2.34, 10.9), delivery at home (AOR=2.82, 95% CI: 1.2, 6.64), absence of maternal PMTCT intervention (AOR=5.02, 95% CI: 2.43, 10.4) and mixed infant feeding practices (AOR=4.18, 95% CI: 1.59, 10.99) were significantly and independently associated with maternal‐to‐child HIV transmission. Conclusion There is a high risk of MTCT of HIV among exposed infants on follow up at the PMTCT clinic of the University of Gondar referral hospital. This finding could push decision‐makers to enhance commitment and support an adequate and sustainable extension of the use of PMTC services to rural mothers, expand services to rural settings in the PMTCT scaling‐up program.