Open AccessICOS, SLAM and PD‐1 expression and regulation on T lymphocytes reflect the immune dysregulation in patients with HIV‐related illness with pulmonary tuberculosis
Author(s) -
Jurado Javier Oscar,
Pasquinelli Virginia,
Alvarez Ivana Belén,
Martínez Gustavo Javier,
Laufer Natalia,
Sued Omar,
Cahn Pedro,
Musella Rosa María,
Abbate Eduardo,
Salomón Horacio,
Quiroga María Florencia
Publication year - 2012
Publication title -
journal of the international aids society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.724
H-Index - 62
ISSN - 1758-2652
DOI - 10.7448/ias.15.2.17428
Subject(s) - medicine , immune system , tuberculosis , immunology , mycobacterium tuberculosis , immune dysregulation , human immunodeficiency virus (hiv) , cytokine , pathology
Background Tuberculosis (TB) continues to be the most frequent cause of illness and death from an infectious agent globally, and its interaction with HIV is having devastating effects. To investigate how HIV alters the immune response to Mycobacterium tuberculosis ( Mtb ), we assessed basal and Mtb ‐induced proliferation, cytokine production, and expression of signalling lymphocytic activation molecule (SLAM), inducible costimulator (ICOS) and programmed death‐1 (PD‐1) on T lymphocytes from HIV‐positive individuals coinfected with TB, HIV‐positive subjects, TB patients and healthy donors (HD). Findings HIV‐TB patients showed increased ICOS, SLAM and PD‐1 basal levels on T lymphocytes, whereas HIV‐positive individuals displayed elevated levels of SLAM and PD‐1, TB patients high levels of SLAM, and HD low levels of the three proteins. Mtb ‐stimulation enhanced ICOS expression in the four groups, but only TB and HD increased SLAM and PD‐1 levels. Conclusions These data show the immune deregulation that takes place during the immune response against TB in different study populations.