Open AccessBackground and Objective: Physical inactivity and low cardio-respiratory fitness are recognized as important causes of morbidity and mortality. In the present study, the Pre and Post-Exercise Changes in Cardio-Pulmonary Functions in Healthy School Children of Gulbarga District were investigated. Materials and Methods: The present work was conducted in the Dept. Of Physiology, M R Medical College, Gulbarga after the institutional ethical clearance. In this study, 50 male students of school aged between 9-11years who are disease free and who were born and brought up in Gulbarga district (Karnataka) with the same socioeconomic status were included. Children with poor nutritional status were excluded from study. Exercise was performed and data were recorded by automatic computerized treadmill. Lung Function Tests and data were recorded by using computerized vitalography. The data were analysed using one-way ANOVA. P value less than 0.05 was the level of significance.Results: The result reflects a Significant increase (p<0.001) in both pre and post exercise changes and a negative correlation(r= 0.048, p=0.05) between BMI and PFI score was observed. Â A significant increase (t=5.16, p<0.001) of exercise induced rise in SBP of school children and no significant difference between pre and post exercise DBP in school children was found. A non-significant change of vital capacity between pre and post exercise and changes of reduction of FEV1 (%) is found to be statistically significant (p<0.05).Conclusion: The percent recovery of heart rate in school children reflects a better cardiovascular efficiency.