SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF THIOCOLCHICOSIDE AND DEXKETOPROFEN TROMETAMOL IN PHARMACEUTICAL DOSAGE FORM | Zendy

JalpeshT Bharatbhai Trivedi | Zendy

Open Access

SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF THIOCOLCHICOSIDE AND DEXKETOPROFEN TROMETAMOL IN PHARMACEUTICAL DOSAGE FORM

Author(s) -

JalpeshT Bharatbhai Trivedi

Publication year - 2012

Publication title -

international journal of biomedical and advance research

Language(s) - English

Resource type - Journals

eISSN - 2455-0558

pISSN - 2229-3809

DOI - 10.7439/ijbar.v3i3.349

Subject(s) - dosage form , traditional medicine , pharmacology , chemistry , medicine

The present manuscript describes simple, sensitive, rapid, accurate, precise and economic dual wavelength spectrophotometric method for simultaneous determination of Thiocolchicoside and Dexketoprofen trometemol in combined tablet dosage form. The utility of dual wavelength data processing program is its ability to calculate unknown concentration of components of interest in a mixture containing an interfering component. The method was based on property of additivity of absorbances. The two wavelengths on UV spectrum of Thiocolchicoside were found out where it showed same absorbance, which were 368 nm and 284.60 nm. At 368 nm Thiocolchicoside showed some absorbance whereas Dexketoprofen trometemol showed zero absorbance. Both the drugs gave absorbance at 284.60 nm. The method involved solving of an equation based on measurement of absorbances at two wavelengths 284.6 and 368 nm. The two drugs follow Beer-Lambertâ€™s law over the concentration range of 2-24 Âµg/ml. The method was successfully applied to pharmaceutical dosage form because no interference from the tablet excipients was found. The results of analysis have been validated statistically and by recovery studies.

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