Open AccessC-reactive protein (CRP) is a widely recognized indicator of inflammation and is known to play an important role in atherogenesis. Recent prospective studies have demonstrated that increased CRP concentrations within the reference interval are a strong predictor of myocardial infarction, stroke, sudden cardiac death, and peripheral vascular disease in apparently healthy adults. The correlation of circulating CRP concentrations with the severity, extent, and progression of many different pathologies, and the prognostic significance of these associations, are consistent with CRP not just being a marker of disease but also contributing to pathogenesis. Knowledge of the structure and function of CRP — including its three-dimensional structure alone and complexed with ligands coupled with experience in developing an inhibitor of the related protein SAP (Amyloid P component, Serum) establishes an excellent platform for drug design