Open AccessCases in Precision Medicine: Genetic Assessment After a Sudden Cardiac Death in the Family
Author(s) -
Ronald Laracuente,
Marc Waase,
Isha Kalia,
Arthur A.M. Wilde,
Wendy K. Chung
Publication year - 2019
Publication title -
annals of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.839
H-Index - 390
eISSN - 1539-3704
pISSN - 0003-4819
DOI - 10.7326/m18-2359
Subject(s) - medicine , genetic testing , autopsy , sudden cardiac death , cause of death , family history , sudden death , anxiety , genetic counseling , risk assessment , intensive care medicine , psychiatry , disease , computer security , biology , computer science , genetics
Sudden death in a family is associated with serious anxiety among family members. Assessing the cause of death may help determine the risk for other family members, thus alleviating some anxiety. In some cases, the cause of death may be evident on autopsy; however, in cases of arrhythmias, standard autopsy will not reveal the cause of death. Evaluation of the circumstances of death, medical history of the deceased, and results of genetic testing may reveal a diagnosis. Once a diagnosis is made, relatives should receive genetic testing and clinical assessment to stratify their risk. Depending on their risk, various interventions are available, including medication, defibrillators, and lifestyle modifications.