Open AccessCases in Precision Medicine: The Role of Pharmacogenetics in Precision Prescribing
Author(s) -
Bohan Lin,
Wendy K. Chung
Publication year - 2019
Publication title -
annals of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.839
H-Index - 390
eISSN - 1539-3704
pISSN - 0003-4819
DOI - 10.7326/m18-2357
Subject(s) - medicine , pharmacogenetics , context (archaeology) , precision medicine , warfarin , intensive care medicine , adverse effect , personalized medicine , drug , affect (linguistics) , pharmacology , medical physics , bioinformatics , pathology , paleontology , biochemistry , chemistry , linguistics , philosophy , biology , genotype , gene , atrial fibrillation
Pharmacogenetics may help physicians deliver individualized treatments based on how a person's genes affect a drug's effects and metabolism. This information can help prevent adverse events or improve drug efficacy by enabling the physician to optimize dosage or to avoid a medication with adverse reactions and to prescribe an alternative therapy. This article discusses the current clinical utility of pharmacogenetic testing in the context of a patient who requires anticoagulation with warfarin.