Open AccessCardioprotector effect of Phosphodiesterase 5 inhibitors in experimental model for Diabetes Mellitus
Author(s) -
Gilson Nogueira Freitas,
Cristina de Oliveira Silva
Publication year - 2021
Publication title -
abcs health sciences
Language(s) - English
Resource type - Journals
eISSN - 2357-8114
pISSN - 2318-4965
DOI - 10.7322/abcshs.2019164.1433
Subject(s) - diabetes mellitus , phosphodiesterase , medicine , diabetic cardiomyopathy , cgmp specific phosphodiesterase type 5 , oxidative stress , cardioprotection , cyclic guanosine monophosphate , nitric oxide , pharmacology , bioinformatics , endocrinology , enzyme , chemistry , biochemistry , biology , myocardial infarction , cardiomyopathy , heart failure , erectile dysfunction
Diabetes mellitus (DM) is considered a 21st century pandemic and is often associated with cardiovascular disease (CVD). The aim of this integrative review was to analyze the cardioprotective effects of phosdodiesterase-5 (PDE5i) inhibitors in experimental diabetes models. The articles were selected from the PubMed, SciElo and LILACS databases from 2014 to 2019. The following descriptors were used in combination with the Boolean operators: Diabetes mellitus experimental AND Phosphodiesterase 5 inhibitors; Diabetic cardiomyopathies AND Phosphodiesterase 5 inhibitors. An initial sample of 155 articles was obtained, of which six met the criteria for the synthesis of the review. The studies analyzed showed that treatment with PDE5i in experimental models, resulted in positive effects on cardiac function and metabolic parameters. Similar results have also been seen in humans. The reduction in cardiac hypertrophy, apoptosis of cardiomyocytes, pro-inflammatory factors and oxidative stress and the modulation of transcription factors involved in diabetes homeostasis, were prevalent among studies. The mechanisms of action involved in cardioprotection have not yet been fully elucidated, however the restoration of the activated cyclic guanosine monofate (cGMP) pathway by soluble guanylate cyclase (sGC) via nitric oxide (NO) was a common mechanism among the studies.