Development of Acrylic Acid Grafted Polycaprolactone (PCL)/Biphasic Calcium Phosphate (BCP) Nanofibers for Bone Tissue Engineering Using Gamma-Irradiation | Zendy

Jin-Oh Jeong | Zendy; Sung In Jeong | Zendy; Young Min Shin | Zendy; JongSeok Park | Zendy; HuiJeong Gwon | Zendy; SungJun An | Zendy; JungBo Huh | Zendy; Heungsoo Shin | Zendy; YounMook Lim | Zendy

Open Access

Development of Acrylic Acid Grafted Polycaprolactone (PCL)/Biphasic Calcium Phosphate (BCP) Nanofibers for Bone Tissue Engineering Using Gamma-Irradiation

Author(s) -

Jin-Oh Jeong,

Sung In Jeong,

Young Min Shin,

JongSeok Park,

HuiJeong Gwon,

SungJun An,

JungBo Huh,

Heungsoo Shin,

YounMook Lim

Publication year - 2015

Publication title -

polymer korea

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.152

H-Index - 18

eISSN - 2234-8077

pISSN - 0379-153X

DOI - 10.7317/pk.2015.39.3.418

Subject(s) - polycaprolactone , nanofiber , electrospinning , biocompatibility , materials science , nuclear chemistry , acrylic acid , phosphate , bone tissue , chemical engineering , biomedical engineering , polymer chemistry , chemistry , composite material , organic chemistry , monomer , polymer , medicine , metallurgy , engineering

Polycaprolactone (PCL)? biphasic calcium phosphate (BCP)? ? ? ?? ?? ??? ?? ???? ??? ???? ??. ???,PCL? ??? ?? ??? ?? ? ??? ??? ?? ???? ?? ? ???? ???? ? ??? ?? ???? ??? PLC/BCP . ?? , ???? ???? acrylic acid (AAc)? . SEM? ?? ?? ?? ??? , AAc? ??? ??? MG63? ?? ???? ??? ??? ?? . ???? ??? 1.239 +/- 0.226 nmole/mu g/min?? ???? ?? ????(0.590 +/- 0.286 nmole/mu g/min)?? .??? AAc? ??? PCL/BCP ??? ??? ??? ? ?? ??? ????. Polycaprolactone (PCL) and biphasic calcium phosphate (BCP) have been considered as useful materials for orthopedic devices and osseous implants because of their biocompatibility and bone-forming activity. However, PCL-based scaffolds have hydrophobic surfaces reducing initial cell adhesion or proliferation. To overcome the limitation, we fabricated surface-modified PCL/BCP nanofibers using gamma-irradiation for bone tissue engineering. PCL/BCP nanofibers were prepared by electrospinning and then we supplemented hydrophilicity by introducing acrylic acid (AAc) through gamma-irradiation. We confirmed the surface of nanofibers by SEM, and then the initial viability of MG63 was significantly increased on the AAc grafted nanofibers, and alkaline phosphatase activity(1.239 +/- 0.226 nmole/mu g/min) improved on the modified nanofibers than that on the non-modified nanofibers(0.590 +/- 0.286 nmole/mu g/min). Therefore, AAc-grafted nanofibers may be a good tool for bone tissue engineering applications.? ??? ???? (2012M2A2A6013196)? (HI14C0744)? ??? ?? ???? ???, ??

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