Open AccessPro-(IL-18) and Anti-(IL-10) Inflammatory Promoter Genetic Variants (Intrinsic Factors) with Tobacco Exposure (Extrinsic Factors) May Influence Susceptibility and Severity of Prostate Carcinoma: A Prospective Study
Author(s) -
Shailendra Dwivedi,
Sarvesh Kumar Singh,
Apul Goel,
Sanjay Khattri,
Anil Mandhani,
Praveen Sharma,
Sanjeev Misra,
Kamlesh Kumar Pant
Publication year - 2015
Publication title -
asian pacific journal of cancer prevention
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 75
eISSN - 2476-762X
pISSN - 1513-7368
DOI - 10.7314/apjcp.2015.16.8.3173
Subject(s) - genotype , prostate cancer , medicine , genetic predisposition , genotyping , prostate , cytokine , malignancy , immunology , oncology , gastroenterology , cancer , biology , disease , genetics , gene
It has been hypothesized that IL-18 (pro-) and IL-10 (anti-) inflammatory genetic variants at -607 C/A-137G/C and -819C/T,-592C/A, respectively, may generate susceptibility and severity risk with various modes of tobacco exposure in prostate carcinoma (PCa) patients. IL-18 is a pro-inflammatory cytokine expressed on various cells including prostate gland elements, and is a key mediator of immune responses with anti-cancerous properties. IL-10 is an anti-inflammatory cytokine that is associated with tumour malignancy which causes immune escape.