Open AccessLeu432Val Polymorphism of CYP1B1 is Not Associated with Squamous Cell Carcinoma of Esophagus - a Case-Control Study from Kashmir, India
Author(s) -
Idrees Ayoub Shah,
Promila Mehta,
Mohd Maqbool Lone,
Nazir Ahmad Dar
Publication year - 2015
Publication title -
asian pacific journal of cancer prevention
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 75
eISSN - 2476-762X
pISSN - 1513-7368
DOI - 10.7314/apjcp.2015.16.13.5337
Subject(s) - genotype , odds ratio , confidence interval , case control study , medicine , biology , gastroenterology , logistic regression , cyp1b1 , esophagus , oncology , genetics , gene , cytochrome p450 , metabolism
Individual susceptibility to cancer has been attributed to polymorphisms in xenobiotic metabolizing genes. To evaluate the association of the Leu432Val polymorphism of cytochrome P4501B1 (CYP1B1) with esophageal squamous cell carcinoma (ESCC), we conducted a case control study in Kashmir, India, an area with a relatively high incidence of ESCC.