Open AccessAssociation between MTHFR C677T Polymorphism and Risk of Prostate Cancer: Evidence from 22 Studies with 10,832 Cases and 11,993 Controls
Author(s) -
Mehdi Abedinzadeh,
Masoud Zare-Shehneh,
Hossein Neámatzadeh,
Maryam Abedinzadeh,
Hormoz Karami
Publication year - 2015
Publication title -
asian pacific journal of cancer prevention
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 75
eISSN - 2476-762X
pISSN - 1513-7368
DOI - 10.7314/apjcp.2015.16.11.4525
Subject(s) - methylenetetrahydrofolate reductase , prostate cancer , odds ratio , medicine , genetic model , oncology , allele , heterozygote advantage , meta analysis , case control study , confidence interval , genotype , gastroenterology , cancer , genetics , biology , gene
The MTHFR C677T polymorphism is a genetic alteration affecting an enzyme involved in folate metabolism, but its relationship to host susceptibility to prostate cancer remains uncertain. The aim of this study was to investigate the association between MTHFR C677T polymorphism and prostate cancer by performing a meta-analysis.