Open AccessAdipo-R1 and Adipo-R2 Expression in Colorectal Adenomas and Carcinomas
Author(s) -
Talat Ayyıldız,
Enver Dolar,
Nesrin Uğraş,
Ahmet Tarık Eminler,
Banu Ertürk,
Şaduman Balaban Adım,
Ömer Yerci
Publication year - 2015
Publication title -
asian pacific journal of cancer prevention
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 75
eISSN - 2476-762X
pISSN - 1513-7368
DOI - 10.7314/apjcp.2015.16.1.367
Subject(s) - adiponectin , colorectal cancer , medicine , dysplasia , oncology , gastroenterology , carcinoma , adipokine , receptor , endocrinology , cancer , cancer research , obesity , insulin resistance
Human adiponectin (ApN), a 30 kDa glycoprotein of 244-amino acids which is predominantly produced by adipocytes, exerts its effects via two receptors, namely adiponectin receptor-1 (adipo-R1) and adiponectin receptor-2 (adipo-R2) with differential binding affinity to globular adiponectin. Adiponectin receptor expression has been studied in several cancer tissues. However, there are no studies of colorectal adenomas which are considered to be precursors for colorectal carcinoma (CRC).