Open AccessHPV-Associated p16INK4AExpression and Response to Therapy and Survival in Selected Head and Neck Cancers
Author(s) -
Gül Kanyılmaz,
Özgür Ekinci,
Akmansu Muge,
Sevinç Çelik,
Furkan Öztürk
Publication year - 2015
Publication title -
asian pacific journal of cancer prevention
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 75
eISSN - 2476-762X
pISSN - 1513-7368
DOI - 10.7314/apjcp.2015.16.1.253
Subject(s) - medicine , stage (stratigraphy) , oncology , head and neck cancer , cancer , immunohistochemistry , hypopharyngeal cancer , squamous cell cancer , paleontology , biology
Development of squamous cell cancer of head and neck (SCCHN) is associated with human papillomavirus (HPV) infection, which in turn is closely related with expression of p16 INK4A. Loss of p16 INK4A expression by deletion, mutation, or hypermethylation is common in SCCHN. We here evaluated p16 INK4A as a prognostic marker of treatment response and survival in our SCCHN patients with laryngeal, hypopharyngeal or nasopharyngeal cancers.