Open AccessA Functional SNP in the MDM2 Promoter Mediates E2F1 Affinity to Modulate Cyclin D1 Expression in Tumor Cell Proliferation
Author(s) -
Zhenhai Yang,
Chunlin Zhou,
Hong Zhu,
JiuHong Li,
Chundi He
Publication year - 2014
Publication title -
asian pacific journal of cancer prevention
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 75
eISSN - 2476-762X
pISSN - 1513-7368
DOI - 10.7314/apjcp.2014.15.8.3817
Subject(s) - e2f1 , gene knockdown , cyclin d1 , cancer research , regulator , carcinogenesis , mdm2 , cell growth , biology , cyclin a , cyclin d , transcription factor , oncogene , microbiology and biotechnology , cell cycle , cancer , cell culture , gene , genetics
The MDM2 oncogene, a negative regulator of p53, has a functional polymorphism in the promoter region (SNP309) that is associated with multiple kinds of cancers including non-melanoma skin cancer. SNP309 has been shown to associate with accelerated tumor formation by increasing the affinity of the transcriptional activator Sp1. It remains unknown whether there are other factors involved in the regulation of MDM2 transcription through a trans-regulatory mechanism.