Open AccessInduction of Apoptosis by IGFBP3 Overexpression in Hepatocellular Carcinoma Cells
Author(s) -
Jianjun Han,
Dong Xue,
Qiu-Rong Han,
Xin Liang,
Li Xie,
Sheng Li,
Hui-yong Wu,
Bao-Liang Song
Publication year - 2015
Publication title -
asian pacific journal of cancer prevention
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 75
eISSN - 2476-762X
pISSN - 1513-7368
DOI - 10.7314/apjcp.2014.15.23.10085
Subject(s) - trichostatin a , igfbp3 , apoptosis , cancer research , cell culture , cell growth , biology , hepatocellular carcinoma , growth factor , pten , demethylating agent , microbiology and biotechnology , dna methylation , gene expression , pi3k/akt/mtor pathway , biochemistry , genetics , gene , receptor , histone deacetylase , histone
The insulin-like growth factor (IGF) system comprises a group of proteins that play key roles in regulating cell growth, differentiation, and apoptosis in a variety of cellular systems. The aim of this study was to investigate the role of insulin-like growth factor binding protein 3 (IGFBP3) in hepatocellular carcinoma.