Open AccessLack of Association between Polymorphisms in Genes MTHFR and MDR1 with Risk of Childhood Acute Lymphoblastic Leukemia
Author(s) -
Madara Kreile,
Dmitrijs Rots,
Linda Piekuse,
Elizabete Cebura,
Marika Grūtupa,
Zhanna Kovalova,
Baiba Lāce
Publication year - 2014
Publication title -
asian pacific journal of cancer prevention
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 75
eISSN - 2476-762X
pISSN - 1513-7368
DOI - 10.7314/apjcp.2014.15.22.9707
Subject(s) - methylenetetrahydrofolate reductase , linkage disequilibrium , proband , allele , disease , case control study , medicine , genetics , haplotype , genetic association , age of onset , oncology , genotype , single nucleotide polymorphism , gene , biology , mutation
Acute lymphoblastic leukemia (ALL) is a complex disease caused by interactions between hazardous exogenous or/and endogenous agents and many mild effect inherited susceptibility mutations. Some of them are known, but their functional roles still requireinvestigation. Age is a recognized risk factor; children with disease onset after the age of ten have worse prognosis, presumably also triggered by inherited factors.