Open AccessTLR9 Expression in Uterine Cervical Lesions of Uyghur Women Correlate with Cervical Cancer Progression and Selective Silencing of Human Papillomavirus 16 E6 and E7 Oncoproteins in Vitro
Author(s) -
Yi Hao,
Jianling Yuan,
Abulizi Abudula,
Axiangu Hasimu,
Nafeisha Kadeer,
Xia Guo
Publication year - 2014
Publication title -
asian pacific journal of cancer prevention
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 75
eISSN - 2476-762X
pISSN - 1513-7368
DOI - 10.7314/apjcp.2014.15.14.5867
Subject(s) - immunohistochemistry , cervicitis , cervical cancer , cervical intraepithelial neoplasia , gene silencing , medicine , pathology , biology , cancer research , cancer , gynecology , gene , biochemistry
Cervical cancer is listed as one of high-incidence endemic diseases in Xinjiang. Our study aimed to evaluate the expression of TLR9 in uterine cervical tissues of Uyghur women and examine associations with clinicopathological variables. We further characterized the direct effects of TLR9 upon the selective silencing of human papillomavirus (HPV) E6 and E7 oncoprotein expression in HPV 16-positive human cervical carcinoma cells treated with siRNA in vitro.