Open AccessFOXA1: a Promising Prognostic Marker in Breast Cancer
Author(s) -
Qing Hu,
Zhongxin Luo,
Tao Xu,
Junying Zhang,
Ying Zhu,
Weixian Chen,
Shanliang Zhong,
Jianhua Zhao,
Jinhai Tang
Publication year - 2014
Publication title -
asian pacific journal of cancer prevention
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 75
eISSN - 2476-762X
pISSN - 1513-7368
DOI - 10.7314/apjcp.2014.15.1.11
Subject(s) - foxa1 , breast cancer , medicine , biomarker , oncology , cancer , biology , biochemistry
Accurate diagnosis and proper monitoring of cancer patients remain important obstacles for successful cancer treatment. The search for cancer biomarkers can aid in more accurate prediction of clinical outcome and may also reveal novel predictive factors and therapeutic targets. One such prognostic marker seems to be FOXA1. Many studies have shown that FOXA1 is strongly expressed in a vast majority of cancers, including breast cancer, in which high expression is associated with a good prognosis. In this review, we summarize the role of this transcription factor in the development and prognosis of breast cancer in the hope of providing insights into utility of FOXA1 as a novel biomarker.