Open AccessGerm-line MTHFR C677T, FV H1299R and PAI-1 5G/4G Variations in Breast Carcinoma
Author(s) -
Filiz Özen,
Eda Erdiş,
Ebru Sik,
Fatma Sılan,
Ahmet Uludağ,
Öztürk Özdemir
Publication year - 2013
Publication title -
asian pacific journal of cancer prevention
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 75
eISSN - 2476-762X
pISSN - 1513-7368
DOI - 10.7314/apjcp.2013.14.5.2903
Subject(s) - methylenetetrahydrofolate reductase , breast cancer , genotyping , medicine , allele frequency , allele , oncology , cancer , case control study , breast carcinoma , gastroenterology , genotype , gynecology , biology , genetics , gene
Various oncogenes related to cancer have been extensively studied and several polymorphisms have been found to be associated with breast cancer. The current report outlines analysis of germ-line polymorphisms for C677T, A1298C (MTHFR), Leiden, R2 (FV) and 5G/4G (PAI-1) in Turkish breast cancer patients. We studied 51 cases diagnosed with invasive ductal and operable with lymph node-positive breast cancer and 106 women as a control group.