Open AccessReduction of Proliferation and Induction of Apoptosis are Associated with Shrinkage of Head and Neck Squamous Cell Carcinoma due to Neoadjuvant Chemotherapy
Author(s) -
Shreya Sarkar,
Guru Prasad Maiti,
Jayesh Kumar Jha,
Jaydip Biswas,
Anup Roy,
Susanta Roychoudhury,
Tyson V. Sharp,
Chinmay Kumar Panda
Publication year - 2013
Publication title -
asian pacific journal of cancer prevention
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 75
eISSN - 2476-762X
pISSN - 1513-7368
DOI - 10.7314/apjcp.2013.14.11.6419
Subject(s) - apoptosis , chemotherapy , cancer research , cisplatin , cell growth , head and neck squamous cell carcinoma , cell cycle , cyclin d1 , cell , cancer , biology , pathology , medicine , oncology , head and neck cancer , biochemistry , genetics
Neoadjuvant chemotherapy (NACT) is a treatment modality whereby chemotherapy is used as the initial treatment of HNSCC in patients presenting with advanced cancer that cannot be treated by other means. It leads to shrinkage of tumours to an operable size without significant compromise to essential oro-facial organs of the patients. The molecular mechanisms behind shrinkage due to NACT is not well elucidated.