Open AccessLack of Association Between LIG4 Gene Polymorphisms and the Risk of Breast Cancer: A HuGE Review and Meta-analysis
Author(s) -
Liping Zhou,
Liang Hong,
Xi-Hua Dong,
Guojiang Jin,
Dongliang Man,
Hong Shang
Publication year - 2012
Publication title -
asian pacific journal of cancer prevention
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 75
eISSN - 2476-762X
pISSN - 1513-7368
DOI - 10.7314/apjcp.2012.13.7.3417
Subject(s) - breast cancer , meta analysis , odds ratio , cochrane library , oncology , medicine , single nucleotide polymorphism , cancer , bioinformatics , gene , genetics , biology , genotype
Non-homologous end joining (NHEJ) is one of the pathways of repair of DNA double-strand breaks. A number of genes involved in NHEJ have been implicated as breast cancer susceptibility genes such as LIG4. However, some studies have generated conflicting results. The aim of this Human Genome Epidemiology (HuGE) review and meta-analysis was to investigate association between LIG4 gene polymorphisms in the NHEJ pathway and breast cancer risk.