Open AccessMLH1 Polymorphisms and Cancer risk: a Meta-analysis Based on 33 Case-control Studies
Author(s) -
Jiali Xu,
Zhiqiang Yin,
MingDe Huang,
Xiefeng Wang,
Wen Gao,
Lingxiang Liu,
Rongsheng Wang,
Pu-Wen Huang,
Yongmei Yin,
Ping Liu,
Yongqian Shu
Publication year - 2012
Publication title -
asian pacific journal of cancer prevention
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 75
eISSN - 2476-762X
pISSN - 1513-7368
DOI - 10.7314/apjcp.2012.13.3.901
Subject(s) - mlh1 , meta analysis , case control study , medicine , cancer , oncology , colorectal cancer , dna mismatch repair
Cumulative evidence suggests that MLH1, the key component in the mismatch pathway, plays an important role in human cancers. Two potential functional polymorphisms (-93G>A and I219V) of MLH1 have been implicated in cancer risk. The aim of this meta-analysis was to summarize the evidence for associations.