Open AccessApoptosis in Cancer - An Update
Author(s) -
S. Leena Sankari,
K. M. K. Masthan,
Niraj Babu,
Tathagata Bhattacharjee,
M. Elumalai
Publication year - 2012
Publication title -
asian pacific journal of cancer prevention
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 75
eISSN - 2476-762X
pISSN - 1513-7368
DOI - 10.7314/apjcp.2012.13.10.4873
Subject(s) - apoptosis , cancer , programmed cell death , cancer research , cytoplasm , biology , pathogenesis , cancer cell , medicine , neuroscience , immunology , bioinformatics , microbiology and biotechnology , genetics
Apoptosis is programmed cell death which is essential for development and survival of living organisms. It is a sequentially regulated suicidal programme where cells activate certain enzymes which dissolute their own nuclear component and various protein component of nucleus and cytoplasm. Disturbance of this regulatory pathway may lead to various diseases like autoimmune diseases, neurodegenerative diseases and cancers. The potential mechanisms of apoptosis and its role in cancer are discussed. The ability of apoptosis to modulate the life or death of a cell is also recognized for its immense therapeutic potential. Understanding the mechanisms from this review will give us better insight to the pathogenesis of various diseases including cancer and will open new horizons to therapeutic approaches.