Open AccessCharacterizing protein domain associations by Small-molecule ligand binding
Author(s) -
Qingliang Li,
Tiejun Cheng,
Yanli Wang,
Stephen H. Bryant
Publication year - 2012
Publication title -
journal of proteome science and computational biology
Language(s) - Uncategorized
Resource type - Journals
ISSN - 2050-2273
DOI - 10.7243/2050-2273-1-6
Subject(s) - small molecule , computational biology , context (archaeology) , protein data bank , drug discovery , structural similarity , protein domain , protein data bank (rcsb pdb) , biology , protein structure , protein–protein interaction , bioinformatics , genetics , biochemistry , paleontology , gene
Protein domains are evolutionarily conserved building blocks for protein structure and function, which are conventionally identified based on protein sequence or structure similarity. Small molecule binding domains are of great importance for the recognition of small molecules in biological systems and drug development. Many small molecules, including drugs, have been increasingly identified to bind to multiple targets, leading to promiscuous interactions with protein domains. Thus, a large scale characterization of the protein domains and their associations with respect to small-molecule binding is of particular interest to system biology research, drug target identification, as well as drug repurposing.