A qualitative analysis of seven ivermectin formulations in South Africa | Zendy

Qasim Bhorat | Zendy; As’ad E. Bhorat | Zendy

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A qualitative analysis of seven ivermectin formulations in South Africa

Author(s) -

Qasim Bhorat,

As’ad E. Bhorat

Publication year - 2021

Publication title -

south african medical journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.527

H-Index - 57

eISSN - 2078-5135

pISSN - 0256-9574

DOI - 10.7196/samj.2021.v111i4.15630

Subject(s) - ivermectin , medicine , active ingredient , ingredient , medical prescription , traditional medicine , chromatography , veterinary medicine , pharmacology , pathology , chemistry

Some South African (SA) healthcare practitioners are promoting the prescription and use of products claiming to contain ivermectin for the treatment and/or prevention of COVID-19 in SA. This study qualitatively analysed seven samples of ivermectin formulations (5 tablet and 2 capsule formulations) being sold in SA for human use. The samples were analysed using a high-performance liquid chromatography instrument connected to a Sciex X500R quadrupole time-of-flight high-resolution mass spectrometer. The study found that all the samples had both the major homologues of ivermectin (B1a and B1b) and also that 4 out of the 5 tablet formulations tested had at least one additional undeclared active pharmaceutical ingredient.

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