Open AccessDrug-allergy investigation, provocation tests
Author(s) -
Lilla Mihályi,
Lajos Kemény,
Zsuzsanna BataCsörgő
Publication year - 2021
Publication title -
bőrgyógyászati és venerológiai szemle
Language(s) - English
Resource type - Journals
eISSN - 2064-261X
pISSN - 0006-7768
DOI - 10.7188/bvsz.2021.97.1.1
Subject(s) - provocation test , drug allergy , medicine , culprit , drug , gold standard (test) , allergy , intensive care medicine , dermatology , pharmacology , immunology , pathology , alternative medicine , myocardial infarction
The authors present the in vivo investigation options in drug allergy. In suspicion of drug induced hypersensitivity reaction prick testing, intradermal testing and patch testing are recommended according to the assumed immuno-mechanism. If these examinations are negative, the next step is the drug provocation test, which is the gold standard in the diagnosis of drug allergy. We summarize methods, indications and contraindications and the evaluationof each test, focusing on issues concerning antibiotics, perioperative medication, local anesthetics and biological agents. There are increasing number of patients presenting hypersensitivity reactions who require proper identification of the culprit drug.