Open AccessThe Natural Course of Total Kidney Volume in Patients with Autosomal Dominant Polycystic Kidney Disease undergoing Hemodialysis
Author(s) -
Ye Na Kim,
Yeonsoon Jung,
Ho Sik Shin,
Hark Rim,
Jung Gu Park,
Dong Yeol Lee,
Joong Kyung Kim
Publication year - 2021
Publication title -
gosin daehakgyo uigwa daehak haksulji/kosin medical journal
Language(s) - English
Resource type - Journals
eISSN - 2586-7024
pISSN - 2005-9531
DOI - 10.7180/kmj.2021.36.2.109
Subject(s) - hemodialysis , medicine , dialysis , autosomal dominant polycystic kidney disease , urology , polycystic kidney disease , nephrology , kidney , surgery
Objectives The natural course of native kidneys after hemodialysis initiation in patients with autosomal dominant polycystic kidney disease (ADPKD) remains poorly understood. Methods We measured the total volumes of native kidneys in 12 patients who had at least one enhanced computed tomography (CT) image both before and after initiation of hemodialysis (group 1) and in 18 patients who had no image before dialysis but more than two images after dialysis (group 2). In patients with images, the last image was used for analysis only after dialysis. Results The mean total kidney volume (TKV) (± SD) before hemodialysis initiation was 3132 ± 1413 mL and the mean TKV of the last image was 3047 ± 1323 mL in group 1. The mean TKV change rate (%) was −5.2 ± 27.4% ( P > 0.05) during follow-up of 3.9 ± 1.9 years in group 1. The mean TKV change rate was 2.8 ± 34.4% ( P > 0.05) in group 2. The follow-up period after dialysis initiation ranged from 4.2 ± 4.7 to 8.0 ± 5.2 years. Conclusions The results suggest that the TKV of native polycystic kidneys decreases substantially after hemodialysis initiation. This reduction occurs mainly during the early post-hemodialysis period and followed by a slow enlargement of TKV.