Open AccessA case of aspirin-resistance probably related to glycemic excursion
Author(s) -
Ilaria Fava,
Raffaele Marfella,
Giuseppe Paolisso,
Maria Rosaria Rizzo
Publication year - 2010
Publication title -
clinical management issues
Language(s) - English
Resource type - Journals
eISSN - 2283-3137
pISSN - 1973-4832
DOI - 10.7175/cmi.v4i4.520
Subject(s) - medicine , diabetes mellitus , aspirin , glycemic , insulin resistance , complication , endothelial dysfunction , risk factor , diabetic angiopathy , cardiology , endocrinology
Diabetes is characterised by development of specific microvascular complications and by a high incidence of accelerated atherosclerosis. Several Authors demonstrated that post-prandial hyperglycaemia is certainly an independent risk factor of vascular complications in type 2 diabetes. The endothelial dysfunction, the oxidative stress, the post-prandial hyperglycaemia and the haemostatic and thrombotic parameters alterations are the principal causes for the cardiovascular risk increase in diabetic patient. For this reason many studies on anti-platelet therapy have been made in order to reduce thrombotic complication of diabetes mellitus. However, data suggest that the clinical efficacy of low-dose aspirin in patients with diabetes is substantially lower than in individuals without diabetes. Indeed, several evidences support the hypothesis that diabetes might represent a case of “aspirin resistance”