Open AccessA case of double leukemia: chronic myeloid leukemia intolerant to imatinib and chronic lymphocytic leukemia
Author(s) -
Miriana Rocchi
Publication year - 2015
Publication title -
clinical management issues
Language(s) - English
Resource type - Journals
eISSN - 2283-3137
pISSN - 1973-4832
DOI - 10.7175/cmi.v4i2s.1071
Subject(s) - medicine , chronic lymphocytic leukemia , imatinib , myeloid leukemia , lymphocytosis , nilotinib , imatinib mesylate , leukemia , chronic leukemia , oncology , acute leukemia
Chronic lymphocytic leukemia (CLL) and chronic myeloid leukemia (CML) are the most common leukemias of the elderly. However, the sequential occurrence of CML followed by CLL in the same patient is extremely rare. We present a report of a 70-year-old man who developed CLL six years after the diagnosis of CML in molecular, cytogenetic and morphologic remission. The diagnosis of CLL is confirmed by peripheral lymphocytosis. The first line therapy in CML in chronic phase is still imatinib, but in the present case the patient was intolerant to imatinib, therefore he switched to nilotinib after few months.