Open AccessTargeting ferroptosis-based cancer therapy using nanomaterials: strategies and applications
Author(s) -
Lianxiang Luo,
Han Wang,
Wen Tian,
Xiaoling Li,
Zheng Zhu,
Riming Huang,
Hui Luo
Publication year - 2021
Publication title -
theranostics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.689
H-Index - 97
ISSN - 1838-7640
DOI - 10.7150/thno.65480
Subject(s) - context (archaeology) , reprogramming , nanomaterials , nanotechnology , cancer treatment , cancer , cancer therapy , cancer research , computer science , medicine , chemistry , biology , cell , materials science , paleontology , biochemistry
As an iron-dependent mode of programmed cell death induced by lipid peroxidation, ferroptosis plays an important role in cancer therapy. The metabolic reprogramming in tumor microenvironment allows the possibility of targeting ferroptosis in cancer treatment. Recent studies reveal that nanomaterials targeting ferroptosis have prospects for the development of new cancer treatments. However, the design ideas of nanomaterials targeting ferroptosis sometimes vary. Therefore, in addition to the need for a systematic summary of these ideas, new ideas and insights are needed to make possible the construction of nanomaterials for effectively targeting this cell death pathway. At the same time, further optimization of nanomaterials design is required to make them appropriate for clinical treatment. In this context, we summarize this cross-cutting research area covering from the known mechanism of ferroptosis to providing feasible ideas for nanomaterials design as well as their clinical application. We aim to provide new insights and enlightenment for the next step in developing new nanomaterials for cancer treatment.