Open AccessA tumor microenvironment responsive nanosystem for chemodynamic/chemical synergistic theranostics of colorectal cancer
Author(s) -
Liying Wang,
Jingya Xia,
Hongjie Fan,
Min Hou,
Huiyang Wang,
Xiaoyan Wang,
Ke Zhang,
Liping Cao,
Xiangrui Liu,
Jun Ling,
Hong Yu,
Xia Wu,
Jihong Sun
Publication year - 2021
Publication title -
theranostics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.689
H-Index - 97
ISSN - 1838-7640
DOI - 10.7150/thno.61651
Subject(s) - tumor microenvironment , chemistry , colorectal cancer , cancer research , reactive oxygen species , drug , cancer , pharmacology , medicine , tumor cells , biochemistry
Rationale: The synergism of new modalities alongside chemodynamic therapy into common chemotherapy has shown promising potential in clinical applications. This paper reports a tumor microenvironment-responsive nanosystem for chemodynamic/chemical synergistic therapy and magnetic resonance imaging (MRI). Methods: The biodegradable nanosystem is synthesized using a surface-modified chain transfer agent for surface-initiated living radical polymerization of the chemotherapeutic drug. Results: In this nanosystem, named CAMNSN@PSN38, the cycling time and solubility of the chemotherapeutic drug are improved. The nanoparticles delivered to tumor tissues gradually release the chemotherapeutic drug and Mn 2+ through glutathione (GSH)-triggered biodegradation in the tumor microenvironment. SN38, the released chemotherapeutic drug, not only shows excellent chemical therapy effects but also improves the generation of H 2 O 2 . Furthermore, with the Fenton-like agent Mn 2+ , the generation of reactive oxygen species (ROS) is improved markedly. Finally, CAMNSN@PSN38 shows excellent inhibition of tumor growth in three colorectal cancer tumor models, with an improved accumulation of ROS and controlled release of SN38. Conclusions: The CAMNSN@PSN38-mediated chemodynamic/chemical synergistic therapy provides a promising paradigm for the treatment and MRI-guided therapy of colorectal cancer.