Open AccessSilicon nanowires decorated with platinum nanoparticles were applied for photothermal-enhanced sonodynamic therapy
Author(s) -
Lirong Sun,
Xianwen Wang,
Fei Gong,
Kui Yin,
Wenxiang Zhu,
Nailin Yang,
Shang Bai,
Fan Liao,
Mingwang Shao,
Liang Cheng
Publication year - 2021
Publication title -
theranostics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.689
H-Index - 97
ISSN - 1838-7640
DOI - 10.7150/thno.58755
Subject(s) - sonodynamic therapy , photothermal therapy , nanotechnology , photothermal effect , silicon nanowires , hydrogen peroxide , materials science , nanoparticle , phototoxicity , reactive oxygen species , nanowire , chemistry , organic chemistry , biochemistry , in vitro
Sonodynamic therapy (SDT) triggered by ultrasound (US) can overcome pivotal limitations of photo-therapy owing to its high depth-penetration and low phototoxicity. However, there is still a need to develop more efficient sonosensitizes to enhance the therapy efficiency. Methods: In this study, Pt nanoparticles (Pt NPs) are reduced on silicon nanowires (SiNWs) by in situ reduction to prepare Si-Pt nanocomposites (Si-Pt NCs). Results: Si-Pt NCs can produce reactive oxygen radicals (ROS) under ultrasound (US) irradiation, which have sonodynamic therapy (SDT) effect. Meanwhile, Si-Pt NCs can convert excess hydrogen peroxide (H 2 O 2 ) into ROS in the tumor microenvironment, which endow strong chemodynamic therapy (CDT) effect. Taking the advantages of the mesoporous structure of SiNWs, the SDT and CDT effects of Si-Pt NCs are stronger than those of the pure Pt NPs and SiNWs. Besides, the mild photothermal effect of Si-Pt NCs further improves the SDT&CDT activity and realizes the combined cancer therapy. Conclusion: The developed Si-Pt NCs with the ability of photothermal enhanced SDT/CDT combined therapy play a momentous role in the novel cancer treatment.