Open AccessSystemic disease as a model for development of the genetic ang cell terapy technologies
Author(s) -
В. А. Кордюм,
Д. М. Іродов,
M. V. Drahulian,
T. P. Gulko,
P. V. Buchek
Publication year - 2016
Publication title -
vìsnik ukraïnsʹkogo tovaristva genetikìv ì selekcìonerìv
Language(s) - English
Resource type - Journals
eISSN - 2415-3680
pISSN - 1810-7834
DOI - 10.7124/visnyk.utgis.14.1.540
Subject(s) - carbon tetrachloride , systemic administration , systemic circulation , disease , medicine , immunology , biology , chemistry , pathology , microbiology and biotechnology , organic chemistry , in vivo
Aim. Injury using CCl4 triggers a cascade of reactions and conditions specific for systemic lesions caused by most external anthropogenic environmental factors. Conditions for obtaining a model of systemic injury of an organism have been developed for further performing of restoration technologies with the use of stem cells and cytokines. Methods. Tumor predisposed ICR mice were chosen as the model. Systemic damage was caused with multiple intraperitoneal administration of carbon tetrachloride. Results. The optimal doses and load duration, excess above which leads to irreversible changes in the body that are not amenable to self-healing, were found. Conclusions. The model obtained can be used to study various recovery technologies of systemic damages.Keywords: systemic disease, model, carbon tetrachloride.