Open AccessGenetic features of the glutathyon system of long livers of Carpathian region with comorbid pathology: arterial hypertension and osteoarthrosis
Author(s) -
Ruslan Kozoviy,
L. Ye. Kovalchuk,
H. M. Ersteniuk
Publication year - 2018
Publication title -
faktori eksperimentalʹnoï evolûcìï organìzmìv
Language(s) - English
Resource type - Journals
eISSN - 2415-3826
pISSN - 2219-3782
DOI - 10.7124/feeo.v23.1014
Subject(s) - genotype , glutathione peroxidase , glutathione , glutathione reductase , osteoarthritis , antioxidant , medicine , gene , gene polymorphism , endocrinology , enzyme , polymorphism (computer science) , peroxidase , glutathione s transferase , biology , pathology , genetics , biochemistry , alternative medicine
Aim. To study the polymorphism of GSTM1, GSTT1 genes. To study the activity of enzymes encoding these genes in long-livers with arterial hypertension (AG) and osteoarthritis (OA). Methods. The determination of the frequency of polymorphous variants of gene deletions GSTT1 and GSTM1 and the activity of glutathione S-transferase (GST), glutathione reductase (GRD), glutathione peroxidase (GPO) was performed in long-livers, who were separated depending on the presence AG and OA. Results. In the group of patients with hypertension and OA genotype GSTM1«+»/GSTT1«+» met the GSTM1«+»/GSTT1«-» 3.0 times more often. The genotype GSTM1«-»/GSTT1«+» in comparison with GSTM1«-»/GSTT1«-» in this study group was 3.17 times. The study of GPO, GRD, and GST enzymes has shown a tendency to depend on its level from the health of long-livers. Conclusions. The advantage of genotypes with the active form of the gene GSTT1«+» was spotted among healthy long livers and patients with hypertension and OA. It indicates a better functioning of the antioxidant defense system. The activity of the enzymes of the glutathione system GPO, GRD, and GST was higher in healthy long-livers livers than in patients with comorbid pathology.
Keywords: glutathione system, longevity, arterial hypertension, osteoarthritis.