Open AccessResults of mutation status gene HER-2/NEU in patients with breast cancer in Ukraine
Author(s) -
B. T. Klimuk,
О. М. Дуган,
A. V. Stefanovych,
Sergiy Klymenko
Publication year - 1970
Publication title -
faktori eksperimentalʹnoï evolûcìï organìzmìv
Language(s) - English
Resource type - Journals
eISSN - 2415-3826
pISSN - 2219-3782
DOI - 10.7124/feeo.v21.860
Subject(s) - fish <actinopterygii> , breast cancer , oncology , medicine , mutation , gene , gene mutation , chemotherapy , human epidermal growth factor receptor 2 , her2/neu , cancer , biology , genetics , fishery
Aim. Detection of changes in epidermal growth factor receptor 2 (HER-2/Neu) in tumor cells is critical to patient prognosis, prediction of response to standard chemotherapy, and perspectives for the treatment of anti-HER-2 therapy. Methods. The research study was conducted according to the recommendations of ASCO/CAP 2013 to diagnose cases of determining gene expression HER-2/Neu by FISH. To identify the exact status of the gene HER-2/Neu TP53 marker was selected. Results. A statistically significant difference (χ2 = 3.36, p>0.05) was found among the questionable cases of mutated HER-2 / neu in the patient groups which was surveyed according to 2007 and 2013 years recommendations. Conclusions. In comparison with 2007 ASCO/CAP 2007 (from 1.4 % to 4.2 %) 2013 ASCO/CAP showed more cases which was classified as doubtful during the test with two-color breakdown HER-2/CEP17.
Keywords: HER-2/Neu, mutation status, FISH, centromere area, TP53.