Open AccessStudy on the mechanism of Jiawei Linggui Zhugan Decoction in the treatment of myelodysplastic syndrome based on network pharmacological analysis
Author(s) -
Binyan Mo
Publication year - 2021
Publication title -
medical research
Language(s) - English
Resource type - Journals
eISSN - 2664-0341
pISSN - 2664-0333
DOI - 10.6913/mrhk.202109_3(3).0006
Subject(s) - kegg , decoction , mechanism (biology) , computational biology , signal transduction , traditional chinese medicine , function (biology) , biology , mechanism of action , traditional medicine , pharmacology , medicine , bioinformatics , microbiology and biotechnology , genetics , gene , philosophy , gene expression , alternative medicine , transcriptome , epistemology , pathology , in vitro
the research method of network pharmacology is used to explore the material basis and mechanism of modified Linggui Zhugan Decoction in the treatment of myelodysplastic syndrome. Methods: the main active components of 8 traditional Chinese medicines of Jiawei Linggui Zhugan Decoction were searched through tcmsp database, and the target was predicted. The relevant targets of myelodysplastic syndrome were searched through geo database, and the common action targets were obtained by intersection of traditional Chinese medicine targets and disease targets. The core targets were selected by topological analysis with Cytoscape software. Finally, go-bp biological function enrichment and KEGG pathway analysis were carried out based on R software. Results: according to the database analysis, there were 248 active compounds and 3695 targets in the modified Linggui Zhugan decoction, of which 34 were common targets with metabolic syndrome; Through the topological analysis of common targets, 9 core targets were selected. Go-bp biological function enrichment and KEGG pathway analysis found that it can play its therapeutic role through p53, AGE-RAGE, cellular sensitivity, NF KB and other signal pathways. Conclusion: modified Linggui Zhugan decoction may play a therapeutic role through p53 signaling pathway, AGE-RAGE signaling pathway, cellular sensitivity, NF kappa B signaling pathway and cell cycle, so as to provide a new scientific basis for its clinical and basic research.