Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital | Zendy

Thais T. Fink | Zendy; Heloísa Helena de Sousa Marques | Zendy; Bruno Gualano | Zendy; Lívia Lindoso | Zendy; Vera Bain | Zendy; Camilla Astley | Zendy; Fernanda Martins | Zendy; Denise Matheus | Zendy; Olivia Mari Matsuo | Zendy; Priscila Suguita | Zendy; Vitor Trindade | Zendy; Camila Sanson Yoshino de Paula | Zendy; Sylvia Costa Lima Farhat | Zendy; Patrícia Palmeira | Zendy; Gabriela Nunes Leal | Zendy; Lisa Suzuki | Zendy; Vicente Odone Filho | Zendy; Magda CarneiroSampaio | Zendy; Alberto J. S. Duarte | Zendy; Leila Antonângelo | Zendy; Linamara Rizzo Battistella | Zendy; Guilherme V. Polanczyk | Zendy; Rosa Maria Rodrigues Pereira | Zendy; Carlos Roberto Ribeiro de Carvalho | Zendy; Carlos Alberto Buchpiguel | Zendy; Ana Claudia Latrônico | Zendy; Marília Seelaender | Zendy; Clóvis A. Silva | Zendy; Maria Fernanda Bádue Pereira | Zendy; Adriana Maluf Elias Sallum | Zendy; Alexandra Brentani | Zendy; Álvaro J. SantosNeto | Zendy; Amanda Ihara | Zendy; Andrea R Santos | Zendy; Ana Pinheiro Machado Canton | Zendy; Andréia Watanabe | Zendy; Angélica Carreira dos Santos | Zendy; Antônio Carlos Pastorino | Zendy; Bernadette Dora Gombossy de Melo Franco | Zendy; Bruna Caruzo | Zendy; Carina Ceneviva | Zendy; Carolina Campagnoli Machado Freire Martins | Zendy; Danilo Marcelo Leite do Prado | Zendy; Deipara Monteiro Abellan | Zendy; Fabiana Braga Benatti | Zendy; Fabiana Smaria | Zendy; Fernanda de Toledo Gonçalves | Zendy; Fernando Domingues Penteado | Zendy; Gabriela S F de Castro | Zendy; GUILHERME SALLES DE ESCOBAR GONÇALVES | Zendy; Hamilton Roschel | Zendy; Ilana Roitman Disi | Zendy; Isabela G. Marques | Zendy; Inar A. Castro | Zendy; Izabel M. Buscatti | Zendy; Jaline Zandonato Faiad | Zendy; Jarlei Fiamoncini | Zendy; Joaquim Carlos Rodrigues | Zendy; Jorge David Aivazoglou Carneiro | Zendy; José Albino da Paz | Zendy; Juliana Caires de Oliveira Achili Ferreira | Zendy; Katia Regina da Silva | Zendy; Karina L M Bastos | Zendy; Kátia Tomie Kozu | Zendy; Lílian Maria Cristófani | Zendy; Lucas V B Souza | Zendy; Lúcia Maria Arruda Campos | Zendy; Luiz Vicente R F Silva Filho | Zendy; Marcelo Tatit Sapienza | Zendy; Marcos Santos Lima | Zendy; Marlene Pereira Garanito | Zendy; Márcia F A Santos | Zendy; Mayra Dorna | Zendy; Nádia Emi Aikawa | Zendy; Nadia Litvinov | Zendy; Neusa Keico Sakita | Zendy; Paula V.V. Gaiolla | Zendy; Paula Lage Pasqualucci | Zendy; Ricardo Katsuya Toma | Zendy; Simone Corrêa-Silva | Zendy; Sofia Mendes Sieczkowska | Zendy; Marta Imamura | Zendy; Silvana Forsait | Zendy; Vera Aparecida dos Santos | Zendy; Yingying Zheng | Zendy

Open Access

Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital

Author(s) -

Thais T. Fink,

Heloísa Helena de Sousa Marques,

Bruno Gualano,

Lívia Lindoso,

Vera Bain,

Camilla Astley,

Fernanda Martins,

Denise Matheus,

Olivia Mari Matsuo,

Priscila Suguita,

Vitor Trindade,

Camila Sanson Yoshino de Paula,

Sylvia Costa Lima Farhat,

Patrícia Palmeira,

Gabriela Nunes Leal,

Lisa Suzuki,

Vicente Odone Filho,

Magda CarneiroSampaio,

Alberto J. S. Duarte,

Leila Antonângelo,

Linamara Rizzo Battistella,

Guilherme V. Polanczyk,

Rosa Maria Rodrigues Pereira,

Carlos Roberto Ribeiro de Carvalho,

Carlos Alberto Buchpiguel,

Ana Claudia Latrônico,

Marília Seelaender,

Clóvis A. Silva,

Maria Fernanda Bádue Pereira,

Adriana Maluf Elias Sallum,

Alexandra Brentani,

Álvaro J. SantosNeto,

Amanda Ihara,

Andrea R Santos,

Ana Pinheiro Machado Canton,

Andréia Watanabe,

Angélica Carreira dos Santos,

Antônio Carlos Pastorino,

Bernadette Dora Gombossy de Melo Franco,

Bruna Caruzo,

Carina Ceneviva,

Carolina Campagnoli Machado Freire Martins,

Danilo Marcelo Leite do Prado,

Deipara Monteiro Abellan,

Fabiana Braga Benatti,

Fabiana Smaria,

Fernanda de Toledo Gonçalves,

Fernando Domingues Penteado,

Gabriela S F de Castro,

GUILHERME SALLES DE ESCOBAR GONÇALVES,

Hamilton Roschel,

Ilana Roitman Disi,

Isabela G. Marques,

Inar A. Castro,

Izabel M. Buscatti,

Jaline Zandonato Faiad,

Jarlei Fiamoncini,

Joaquim Carlos Rodrigues,

Jorge David Aivazoglou Carneiro,

José Albino da Paz,

Juliana Caires de Oliveira Achili Ferreira,

Katia Regina da Silva,

Karina L M Bastos,

Kátia Tomie Kozu,

Lílian Maria Cristófani,

Lucas V B Souza,

Lúcia Maria Arruda Campos,

Luiz Vicente R F Silva Filho,

Marcelo Tatit Sapienza,

Marcos Santos Lima,

Marlene Pereira Garanito,

Márcia F A Santos,

Mayra Dorna,

Nádia Emi Aikawa,

Nadia Litvinov,

Neusa Keico Sakita,

Paula V.V. Gaiolla,

Paula Lage Pasqualucci,

Ricardo Katsuya Toma,

Simone Corrêa-Silva,

Sofia Mendes Sieczkowska,

Marta Imamura,

Silvana Forsait,

Vera Aparecida dos Santos,

Yingying Zheng

Publication year - 2021

Publication title -

clinics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.618

H-Index - 61

eISSN - 1980-5322

pISSN - 1807-5932

DOI - 10.6061/clinics/2021/e3511

Subject(s) - medicine , longitudinal study , prospective cohort study , pediatrics , quality of life (healthcare) , anthropometry , observational study , covid-19 , disease , pathology , nursing , infectious disease (medical specialty)

OBJECTIVES: To prospectively evaluate demographic, anthropometric and health-related quality of life (HRQoL) in pediatric patients with laboratory-confirmed coronavirus disease 2019 (COVID-19) METHODS: This was a longitudinal observational study of surviving pediatric post-COVID-19 patients (n=53) and pediatric subjects without laboratory-confirmed COVID-19 included as controls (n=52) was performed. RESULTS: The median duration between COVID-19 diagnosis (n=53) and follow-up was 4.4 months (0.8-10.7). Twenty-three of 53 (43%) patients reported at least one persistent symptom at the longitudinal follow-up visit and 12/53 (23%) had long COVID-19, with at least one symptom lasting for >12 weeks. The most frequently reported symptoms at the longitudinal follow-up visit were headache (19%), severe recurrent headache (9%), tiredness (9%), dyspnea (8%), and concentration difficulty (4%). At the longitudinal follow-up visit, the frequencies of anemia (11% versus 0%, p =0.030), lymphopenia (42% versus 18%, p =0.020), C-reactive protein level of >30 mg/L (35% versus 0%, p =0.0001), and D-dimer level of >1000 ng/mL (43% versus 6%, p =0.0004) significantly reduced compared with baseline values. Chest X-ray abnormalities (11% versus 2%, p =0.178) and cardiac alterations on echocardiogram (33% versus 22%, p =0.462) were similar at both visits. Comparison of characteristic data between patients with COVID-19 at the longitudinal follow-up visit and controls showed similar age ( p =0.962), proportion of male sex ( p =0.907), ethnicity ( p =0.566), family minimum monthly wage ( p =0.664), body mass index ( p =0.601), and pediatric pre-existing chronic conditions ( p =1.000). The Pediatric Quality of Live Inventory 4.0 scores, median physical score (69 [0-100] versus 81 [34-100], p =0.012), and school score (60 [15-100] versus 70 [15-95], p =0.028) were significantly lower in pediatric patients with COVID-19 at the longitudinal follow-up visit than in controls. CONCLUSIONS: Pediatric patients with COVID-19 showed a longitudinal impact on HRQoL parameters, particularly in physical/school domains, reinforcing the need for a prospective multidisciplinary approach for these patients. These data highlight the importance of closer monitoring of children and adolescents by the clinical team after COVID-19.

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