Dataset from HDX-MS Studies of IgG1 Glycoforms and Their Interactions with the FcγRIa (CD64) Receptor | Zendy

Kyle W. Anderson | Zendy; Kerry Scott | Zendy; Ioannis Karageorgos | Zendy; Elyssia S. Gallagher | Zendy; Tayi Venkata S. | Zendy; Michael Butler | Zendy; Jeffrey W. Hudgens | Zendy

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Dataset from HDX-MS Studies of IgG1 Glycoforms and Their Interactions with the FcγRIa (CD64) Receptor

Author(s) -

Kyle W. Anderson,

Kerry Scott,

Ioannis Karageorgos,

Elyssia S. Gallagher,

Tayi Venkata S.,

Michael Butler,

Jeffrey W. Hudgens

Publication year - 2021

Publication title -

journal of research of the national institute of standards and technology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.202

H-Index - 59

eISSN - 2165-7254

pISSN - 1044-677X

DOI - 10.6028/jres.126.010

Subject(s) - cd64 , chemistry , antibody , mass spectrometry , hydrogen–deuterium exchange , chromatography , receptor , biochemistry , biology , immunology

This document presents hydrogen-deuterium exchange mass spectrometry (HDX-MS) data from measurements of three purified IgG1 glycoform samples, predominantly G0F, G2F, and SAF, in isolation and in complexation with the high-affinity receptor, FcγRIa (CD64). The IgG1 antibody used in this study, aIL8hFc, is a murine-human chimeric IgG1, which inhibits IL-8 binding to human neutrophils.

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