Open AccessDataset from HDX-MS Studies of IgG1 Glycoforms and Their Interactions with the FcγRIa (CD64) Receptor
Author(s) -
Kyle W. Anderson,
Kerry Scott,
Ioannis Karageorgos,
Elyssia S. Gallagher,
S Tayi Venkata,
Michael Butler,
Jeffrey W. Hudgens
Publication year - 2021
Publication title -
journal of research of the national institute of standards and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.202
H-Index - 59
eISSN - 2165-7254
pISSN - 1044-677X
DOI - 10.6028/jres.126.010
Subject(s) - cd64 , chemistry , antibody , mass spectrometry , hydrogen–deuterium exchange , chromatography , receptor , biochemistry , biology , immunology
This document presents hydrogen-deuterium exchange mass spectrometry (HDX-MS) data from measurements of three purified IgG1 glycoform samples, predominantly G0F, G2F, and SAF, in isolation and in complexation with the high-affinity receptor, FcγRIa (CD64). The IgG1 antibody used in this study, aIL8hFc, is a murine-human chimeric IgG1, which inhibits IL-8 binding to human neutrophils.