Open AccessStudy on impact of silver nanoparticles synthesized using aqueous extract of Ganoderma applanatum on thyroid and lipid parameters of albino rat
Author(s) -
Sukumar Dandapat,
Rohit Srivastava,
Manoranjan Sinha
Publication year - 2021
Publication title -
anales de biología
Language(s) - Spanish
Resource type - Journals
eISSN - 1989-2128
pISSN - 1138-3399
DOI - 10.6018/analesbio.43.14
Subject(s) - zeta potential , chemistry , fourier transform infrared spectroscopy , nuclear chemistry , distilled water , horticulture , traditional medicine , nanoparticle , materials science , biology , medicine , chromatography , nanotechnology , chemical engineering , engineering
Se estudió el impacto de SNP cargadas con extracto de Ganoderma applanatum sobre el perfil tiroideo y lipídico de rata. Las SNP (diámetro medio 58,77 nm; potencial zeta - 3,8) mV se analizaron mediante DLS. La microespectroscopía de infrarrojo con transformada de Fourier proporcionó un pico de transmisión amplio y elevado a 3248,12 cm-1, que indica la carga bioquímica del extracto de G. applanatum en la superficie de los SNP. No se observó mortalidad ni cambios de comportamiento en la prueba de toxicidad aguda. El grupo-1 recibió 1 mL de agua destilada, el grupo-2 y el grupo-3 recibieron 200 mg kg-1 y 400 mg kg-1 de nanopartículas respectivamente. Una dosis de 400 mg kg-1 de SNPs mostró una mayor actividad hipertiroidea e hipolipidímica en comparación con el control y la dosis de 200 mg kg-1. Impact of silver nanoparticles loaded with Ganoderma applanatum extract on thyroid and lipid profile of rat were studied. Synthesized SNPs (Average diameter 58.77 nm; -13.8 mV zeta potential) were analysed by dynamic light scattering analysis. Fourier transform infrared spectroscopy provided broad and high transmission peak at 3248.12 cm-1 which indicates the loaded biochemical of the G. applanatum extract on the surface of SNPs. No mortality and behavioural changes were observed in the Acute toxicity test. Group-1 received 1 mL distilled water, group-2 and group-3 received 200 mg kg-1 and 400 mg kg-1 nanoparticles respectively. A 400 mg kg-1 dose of SNPs showed increased hyper thyroid and hypolipidimic activity as compared to control and 200 mg kg-1 dose.