Open AccessAntioxidants and Gene Regulation: The Effects of Vitamins C and E on Estrogen Receptors
Author(s) -
Jeong Ho Nam
Publication year - 2006
Publication title -
elements
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.345
H-Index - 85
eISSN - 2380-6087
pISSN - 2378-0185
DOI - 10.6017/eurj.v2i1.8970
Subject(s) - estrogen receptor , estrogen , nitric oxide , receptor , breast cancer , chemistry , endocrinology , medicine , cancer , biology , cancer research , biochemistry
Research shows that estrogen binding to its receptor plays a role in breast cancer development and that antioxidants possibly mitigate this effect. Past research examined whether various treatments lead to accelerated cell division, but characterization and comparison of the effects of different treatments on gene level expression of the receptor was not accomplished. Initially, the effect of antioxidants on the estrogen receptor expression was investigated, revealing the presence of Vitamins C and E on nitric oxide release (a possible cancer reduction agent) stimulated by estrogen acting on the surface estrogen receptor of breast cancer cells was observed. Generally, Vitamin E was most effective for improving nitric oxide release.