Open AccessMožnosti zdravljenja napredovale Parkinsonove bolezni
Author(s) -
Dušan Flisar,
Nina Župančič Križnar,
Maja Trošt,
Zvezdan Pirtošek
Publication year - 2016
Publication title -
zdravniški vestnik
Language(s) - English
Resource type - Journals
eISSN - 1581-0224
pISSN - 1318-0347
DOI - 10.6016/zdravvestn.1402
Subject(s) - levodopa , apomorphine , medicine , deep brain stimulation , parkinson's disease , dopamine , stimulation , anesthesia , dopamine receptor , disease , dopaminergic
Advanced stage of Parkinson's disease is associated with motor complications: motor fluctuations and dyskinesias. The disease can no longer be satisfactorily treated with oral therapy that is based on treatment with levodopa. Dying of dopamine neurons, a short half-life of levodopa and pulsatile stimulation of dopamine receptors are the main reasons for these complications. Currently, there are three options available to treat the advanced stage of Parkinson's disease: subcutaneous infusion of apomorphine, intrajejunal infusion of levodopa and deep brain stimulation. It is necessary to choose the optimal method of treatment that is most suitable for the individual patient.