Možnosti zdravljenja napredovale Parkinsonove bolezni | Zendy

Dušan Flisar | Zendy; Nina Župančič Križnar | Zendy; Maja Trošt | Zendy; Zvezdan Pirtošek | Zendy

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Možnosti zdravljenja napredovale Parkinsonove bolezni

Author(s) -

Dušan Flisar,

Nina Župančič Križnar,

Maja Trošt,

Zvezdan Pirtošek

Publication year - 2016

Publication title -

slovenian medical journal

Language(s) - English

Resource type - Journals

eISSN - 1581-0224

pISSN - 1318-0347

DOI - 10.6016/zdravvestn.1402

Subject(s) - levodopa , apomorphine , medicine , deep brain stimulation , parkinson's disease , dopamine , stimulation , anesthesia , dopamine receptor , disease , dopaminergic

Advanced stage of Parkinson's disease is associated with motor complications: motor fluctuations and dyskinesias. The disease can no longer be satisfactorily treated with oral therapy that is based on treatment with levodopa. Dying of dopamine neurons, a short half-life of levodopa and pulsatile stimulation of dopamine receptors are the main reasons for these complications. Currently, there are three options available to treat the advanced stage of Parkinson's disease: subcutaneous infusion of apomorphine, intrajejunal infusion of levodopa and deep brain stimulation. It is necessary to choose the optimal method of treatment that is most suitable for the individual patient.

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