Open AccessSynthesis and antibacterial evaluation of novel 1-(2,6-diethylphenyl)-5-oxopyrrolidine derivatives
Author(s) -
Mindaugas Žukauskas,
Birutė Grybaitė,
Rita Vaickelionienė,
Giedrius Vaickelionis,
Jūratė Šiugždaitė,
Vytautas Mickevičius
Publication year - 2020
Publication title -
chemija
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.16
H-Index - 15
eISSN - 2424-4538
pISSN - 0235-7216
DOI - 10.6001/chemija.v31i4.4327
Subject(s) - hydrazide , hydrazone , azole , antibacterial activity , chemistry , thio , combinatorial chemistry , pyrazole , stereochemistry , organic chemistry , antifungal , biology , microbiology and biotechnology , bacteria , genetics
Synthesis of 1-(2,6-diethylphenyl)-5-oxopyrrolidine derivatives containing hydrazone, semi/thiosemicarbazide and azole moieties is described. For this purpose, the appropriate hydrazide was treated with aromatic aldehydes, ketones and phenyl iso(thio)cyanates to obtain the desired outcome. The synthesized target compounds were evaluated for their antibacterial properties. The antibacterial screening revealed promising compounds with a pyrazole and thiosemicarbazide moieties in the molecule, which in some cases appeared to be 4 times more effective than Ampicillin.