Open AccessHeadspace gas chromatographic analysis of residual solvents in pharmaceuticals: comparison of two matrix media
Author(s) -
Vida Vičkačkaitė,
Agnieška Jevtuch,
Vilius Poškus,
Birutė Bugelytė
Publication year - 2020
Publication title -
chemija
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.16
H-Index - 15
eISSN - 2424-4538
pISSN - 0235-7216
DOI - 10.6001/chemija.v31i4.4323
Subject(s) - choline chloride , deep eutectic solvent , ethylene glycol , solvent , analyte , chromatography , eutectic system , matrix (chemical analysis) , residual , chemistry , detection limit , dimethylformamide , gas chromatography , organic chemistry , alloy , algorithm , computer science
Dimethylformamide (DMF) and a deep eutectic solvent choline chloride-ethylene glycol (ChCl-Eg) were investigated as potential matrix media for static headspace gas chromatographic (SHS-GC) determination of residual solvents in pharmaceuticals. Sample equilibration temperature, equilibration time and injection time were optimized. In the case of DMF 140°C equilibration temperature was applied. For ChCl-Eg equilibration temperature could not exceed 80°C as ChCl-Eg started to degrade at elevated temperatures. The higher equilibration temperature of DMF solutions favoured a transition of the analytes to the headspace and consequently resulted in lower detection limits of the analytes. Thus DMF has been considered a more suitable matrix medium than ChCl-Eg and was applied for the SHS-GC determination of residual solvents in pharmaceuticals.