Open AccessRelationship between the rs333 Polymorphism in the CC Chemokine Receptor Type Five (CCR5) Gene and Immunological Disorders: Data from a Meta-Analysis
Author(s) -
Felipe Rodolfo Pereira da Silva,
Post Graduation Program in Basic,
Alessandro Luiz Araújo Bentes Leal,
Reyce Santos Koga,
Even Herlany Pereira Alves,
John Arlley Sousa Pinho de Lira,
Humbelina Alves da Silva,
Karen Neisman Rodríguez Ayala,
Paulo Gomes,
Anna Carolina Toledo da Cunha Pereira,
Daniel Fernando Pereira Vasconcelos
Publication year - 2021
Publication title -
international journal of statistics in medical research
Language(s) - English
Resource type - Journals
ISSN - 1929-6029
DOI - 10.6000/1929-6029.2021.10.08
Subject(s) - meta analysis , odds ratio , confidence interval , medicine , periodontitis , publication bias , polymorphism (computer science) , allele , case control study , immunology , gene , biology , genetics
Inflammatory Bowel Disease (IBD), periodontitis and Systemic Lupus Erythematous (SLE) are multifactorial diseases, one of the factors in the course of these diseases is the rs333 polymorphism in the CC chemokine receptor type five (CCR5) gene. However, the results remain contradictory. Therefore, we aimed to perform a meta-analysis evaluating the relation between this polymorphism and the aforementioned conditions. Material and Methods: A search in the literature was performed in diverse scientific and medical databases for studies published before June 22, 2020. The data were extracted from the studies and the statistical evaluation was performed by the calculations of statistical heterogeneity (I²), Odds Ratio (OR) with 95% of Confidence Intervals (CI) and publication bias. The values of P<0.05 were considered as significant for all calculations. Results: 19 articles with 21 case/control studies in 4,304 case patients and 3,492 controls were included. The meta-analysis showed a non-significant association among the rs333 polymorphism and IBD (OR = 1.05, 95% CI: 0.91-1.20, P = 0.51), periodontitis (OR = 0.86, 95% CI: 0.64-1.17, P = 0.34) or SLE (OR = 1.00, 95% CI: 0.56-1.80, P = 1.00) under the allelic model or for any other performed calculation. There were no obvious publication bias in the analyses. Conclusion: In conclusion, this current meta-analysis evidenced the non-significant relation among the rs333 polymorphism and the risk of IBD, periodontitis or SLE. Further studies are required to validate our data.