Open AccessNitric Oxide Metabolites Change in Cisplatin-Induced Nephrotoxicity: The Effect of L-Arginine and Losartan
Author(s) -
Nematbakhsh
Publication year - 2013
Publication title -
journal of analytical oncology
Language(s) - English
Resource type - Journals
eISSN - 1927-7210
pISSN - 1927-7229
DOI - 10.6000/1927-7229.2013.02.02.9
Subject(s) - nephrotoxicity , losartan , nitrite , nitric oxide , arginine , chemistry , pharmacology , cisplatin , nitrate , toxicity , medicine , biochemistry , angiotensin ii , chemotherapy , receptor , amino acid , organic chemistry
Cisplatin (CP) is an anticancer drug with the most common side effect of nephrotoxicity. CP also alters the level of nitric oxide (NO), and NO itself may promote CP-induced nephrotoxicity. In this short report, we measured the serum levels of NO metabolites in an animal model of CP-induced nephrotoxicity, and tested the effect of two nephroprotectant agents; l-arginine and losartan on serum levels of NO metabolites. The results indicated that CP increased the serum concentration of nitrite but not nitrate. However, l-arginine and losartan significantly decreased the serum level of nitrite. It seems that l-arginine and losartan provide their nephroprotectant effect against CP-induced nephrotoxicity by reducing the serum level of nitrite.