Open AccessConcise Review: Paracrine Functions of Vascular Niche Cells in Regulating Hematopoietic Stem Cell Fate
Author(s) -
Sasine Joshua P.,
Yeo Kelly T.,
Chute John P.
Publication year - 2017
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2016-0254
Subject(s) - paracrine signalling , stem cell , microbiology and biotechnology , haematopoiesis , biology , regeneration (biology) , stromal cell , bone marrow , hematopoietic stem cell , endothelial stem cell , clinical uses of mesenchymal stem cells , mesenchymal stem cell , adult stem cell , immunology , cancer research , receptor , genetics , in vitro
The functions of endothelial cells (ECs) in regulating oxygen delivery, nutrient exchange, coagulation, and transit of inflammatory cells throughout the body are well‐‐established. ECs have also been shown to regulate the maintenance and regeneration of organ‐specific stem cells in mammals. In the hematopoietic system, hematopoietic stem cells (HSCs) are dependent on signals from the bone marrow (BM) vascular niche for their maintenance and regeneration after myelosuppressive injury. Recent studies have demonstrated the essential functions of BM ECs and perivascular stromal cells in regulating these processes. In the present study, we summarize the current understanding of the role of BM ECs and perivascular cells in regulating HSC maintenance and regeneration and highlight the contribution of newly discovered EC‐derived paracrine factors that regulate HSC fate. S tem C ells T ranslational M edicine 2017;6:482–489